Simparica Trio price comparison
Simparica Trio is a monthly prescription chew for dogs that covers fleas, ticks, heartworm disease, roundworms, and hookworms in one dose. It is one of the most prescribed combination preventatives in the US, which also makes it one of the meds vets most commonly mark up.
| Pharmacy | Price | per dose | Last checked | Link |
|---|---|---|---|---|
| 1-800-PetMeds Lowest per dose | $217.48 | $36.25 | Jul 18, 2026 | Check price → |
| Allivet | $217.48 | $36.25 | Jul 18, 2026 | Check price → |
| PetCareRx List price $255.06; extra discount in cart with code CARE25 | $217.49 | $36.25 | Jul 18, 2026 | Check price → |
| Chewy | Check site | — | First check pending | Check price → |
| Costco Pharmacy Membership required. No affiliate program exists, and we include it anyway: proof that rankings are not pay to play. | Check site | — | First check pending | In warehouse / member site |
| Petco | Check site | — | First check pending | Check price → |
| Walmart Pet Rx | Check site | — | First check pending | Check price → |
Ranked by verified per dose only; ties listed alphabetically. Unverified pharmacies are listed alphabetically below priced ones. Outbound links may become affiliate links; that never affects the order. Disclosure · Methodology
Price history: tracking since Jul 18, 2026. Trend charts appear once we have multiple verified checks on record.
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Why the same box costs so much more at the vet
Vet clinics buy medications in small quantities and price them with a margin that helps keep the practice running. That is not a scam, but it does mean paying 2 to 3 times the online price for the identical product is common.
Large online pharmacies buy in volume and compete with each other in public, which pushes prices down. Promotions move prices around too: first-order coupons and autoship discounts can shift the effective price by 5 to 30 percent, so we list base prices and note promotions separately instead of mixing them together.
For prescription meds like Simparica Trio, every accredited pharmacy performs the same step: it contacts your vet and verifies the prescription before shipping. The verification is identical everywhere, so a higher price does not buy better service.
Common questions
Do I need a prescription for Simparica Trio?
Yes. Simparica Trio is a prescription medication. Accredited online pharmacies will ask for your vet's contact information and confirm the prescription directly with the clinic, usually within a day or two.
Why is Simparica Trio cheaper online than at my vet?
Vet clinics typically buy in small quantities and add a margin that helps fund the practice. Large online pharmacies buy in volume and compete directly with each other on price, which routinely puts them 20 to 50 percent below in-clinic prices for the same box.
Is there a generic version of Simparica Trio?
No. As of mid-2026 there is no FDA-approved generic equivalent. If cost is a concern, ask your vet whether a different combination of preventatives would suit your dog.
General information only, not veterinary advice. Always consult your veterinarian about your pet's medications.